Correlations among the plasma concentrations of first-line anti-tuberculosis drugs and the physiological parameters influencing concentrations

• Main Authors: Lin Cheng (Author), Ming Luo (Author), Yan Guo (Author), Yunfan Fan (Author), Pengsen Wang (Author), Gang Zhou (Author), Shiwei Qin (Author), Bangbi Weng (Author), Peibo Li (Author), Zhirui Liu (Author), Songtao Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The plasma concentrations of the four most commonly used first-line anti-tuberculosis (TB) drugs, isoniazid (INH), rifampicin (RMP), ethambutol (EMB), and pyrazinamide (PZA), are often not within the therapeutic range. Insufficient drug exposure could lead to drug resistance and treatmen...