Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease

• Κύριοι συγγραφείς: Bowen Sun (Συγγραφέας), Xifan Wang (Συγγραφέας), Xiaoxue Liu (Συγγραφέας), Longjiao Wang (Συγγραφέας), Fazheng Ren (Συγγραφέας), Xiaoyu Wang (Συγγραφέας), Xiaojing Leng (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2020-08-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Chronic kidney disease (CKD) is characterized by the accumulation of protein-bound uremic toxins (PBUTs), which play a pathophysiological role in renal fibrosis (a common pathological process resulting in CKD progression). Accumulation of the PBUT hippuric acid (HA) is positively correlated with dis...