Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease

• मुख्य लेखकों: Bowen Sun (लेखक), Xifan Wang (लेखक), Xiaoxue Liu (लेखक), Longjiao Wang (लेखक), Fazheng Ren (लेखक), Xiaoyu Wang (लेखक), Xiaojing Leng (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2020-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Chronic kidney disease (CKD) is characterized by the accumulation of protein-bound uremic toxins (PBUTs), which play a pathophysiological role in renal fibrosis (a common pathological process resulting in CKD progression). Accumulation of the PBUT hippuric acid (HA) is positively correlated with dis...