Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease

• Main Authors: Bowen Sun (Author), Xifan Wang (Author), Xiaoxue Liu (Author), Longjiao Wang (Author), Fazheng Ren (Author), Xiaoyu Wang (Author), Xiaojing Leng (Author)
• Format: Bog
• Udgivet: MDPI AG, 2020-08-01T00:00:00Z.
• Fag: article
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Chronic kidney disease (CKD) is characterized by the accumulation of protein-bound uremic toxins (PBUTs), which play a pathophysiological role in renal fibrosis (a common pathological process resulting in CKD progression). Accumulation of the PBUT hippuric acid (HA) is positively correlated with dis...