Noncanonical NF-κB Signaling Upregulation in Inflammatory Bowel Disease Patients is Associated With Loss of Response to Anti-TNF Agents

• Main Authors: Vu Q. Nguyen (Author), Kristin Eden (Author), Holly A. Morrison (Author), Megan B. Sammons (Author), Kristin K. Knight (Author), Siena Sorrentino (Author), Rebecca M. Brock (Author), Douglas J. Grider (Author), Irving C. Allen (Author), Dario Sorrentino (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Targeting tumor necrosis factor (TNF) with biologic agents, such as infliximab and adalimumab, is a widely used and effective therapeutic strategy in inflammatory bowel disease (IBD). Unfortunately, a significant number of patients fail to respond or lose response over time to these agen...