Aminooxyacetic acid hemihydrochloride inhibits osteoclast differentiation and bone resorption by attenuating oxidative phosphorylation

• Main Authors: Biao Yang (Author), Yuangang Su (Author), Shuai Han (Author), Runfeng Chen (Author), Ran Sun (Author), Kewei Rong (Author), Feng Long (Author), Hailong Teng (Author), Jinmin Zhao (Author), Qian Liu (Author), An Qin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoclasts undergo active metabolic reprogramming to acquire the energy needed during differentiation and bone resorption. Compared with immature osteoclasts, mature osteoclasts comprise higher levels of electron transport chain enzymes and more metabolically active mitochondria. Of all energy meta...