Engineered Sumoylation-Deficient Prdx6 Mutant Protein-Loaded Nanoparticles Provide Increased Cellular Defense and Prevent Lens Opacity

• Main Authors: Bhavana Chhunchha (Author), Eri Kubo (Author), Uday B. Kompella (Author), Dhirendra P. Singh (Author)
• Format: Bog
• Udgivet: MDPI AG, 2021-08-01T00:00:00Z.
• Fag: article
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Aberrant Sumoylation-mediated protein dysfunction is involved in a variety of oxidative and aging pathologies. We previously reported that Sumoylation-deficient Prdx6K^{(lysine)122/142R(Arginine)} linked to the TAT-transduction domain gained stability and protective efficacy. In...