Mequindox Induced Genotoxicity and Carcinogenicity in Mice

• Main Authors: Qianying Liu (Author), Zhixin Lei (Author), Qin Wu (Author), Deyu Huang (Author), Shuyu Xie (Author), Xu Wang (Author), Yuanhu Pan (Author), Zonghui Yuan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mequindox (MEQ), acting as an inhibitor of deoxyribonucleic acid (DNA) synthesis, is a synthetic heterocyclic N-oxides. To investigate the potential carcinogenicity of MEQ, four groups of Kun-Ming (KM) mice (50 mice/sex/group) were fed with diets containing MEQ (0, 25, 55, and 110 mg/kg) for one and...