Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes

• 主要な著者: Anne Ljungars (著者), Carolin Svensson (著者), Anders Carlsson (著者), Elin Birgersson (著者), Ulla-Carin Tornberg (著者), Björn Frendéus (著者), Mats Ohlin (著者), Mikael Mattsson (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2019-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Phage display technology is a common approach for discovery of therapeutic antibodies. Drug candidates are typically isolated in two steps: First, a pool of antibodies is enriched through consecutive rounds of selection on a target antigen, and then individual clones are characterized in a screening...