Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes

• Ngā kaituhi matua: Anne Ljungars (Author), Carolin Svensson (Author), Anders Carlsson (Author), Elin Birgersson (Author), Ulla-Carin Tornberg (Author), Björn Frendéus (Author), Mats Ohlin (Author), Mikael Mattsson (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2019-07-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Phage display technology is a common approach for discovery of therapeutic antibodies. Drug candidates are typically isolated in two steps: First, a pool of antibodies is enriched through consecutive rounds of selection on a target antigen, and then individual clones are characterized in a screening...