Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes

• Auteurs principaux: Anne Ljungars (Auteur), Carolin Svensson (Auteur), Anders Carlsson (Auteur), Elin Birgersson (Auteur), Ulla-Carin Tornberg (Auteur), Björn Frendéus (Auteur), Mats Ohlin (Auteur), Mikael Mattsson (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2019-07-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Phage display technology is a common approach for discovery of therapeutic antibodies. Drug candidates are typically isolated in two steps: First, a pool of antibodies is enriched through consecutive rounds of selection on a target antigen, and then individual clones are characterized in a screening...