Dual Roles of Extracellular Histone H3 in Host Defense: Its Differential Regions Responsible for Antimicrobial and Cytotoxic Properties and Their Modes of Action

• मुख्य लेखकों: Yuri Tanaka (लेखक), Nanako Yamanaka (लेखक), Izumi Koyano (लेखक), Itaru Hasunuma (लेखक), Tetsuya Kobayashi (लेखक), Sakae Kikuyama (लेखक), Shawichi Iwamuro (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2022-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Extracellular histones play a dual role-antimicrobial and cytotoxic-in host defense. In this study, we evaluated the antimicrobial and cytotoxic activities of histone H3 and identified the responsible molecular regions for these properties. Broth microdilution assays indicated that histone H3 exhibi...