Dual Roles of Extracellular Histone H3 in Host Defense: Its Differential Regions Responsible for Antimicrobial and Cytotoxic Properties and Their Modes of Action

• Main Authors: Yuri Tanaka (Author), Nanako Yamanaka (Author), Izumi Koyano (Author), Itaru Hasunuma (Author), Tetsuya Kobayashi (Author), Sakae Kikuyama (Author), Shawichi Iwamuro (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Extracellular histones play a dual role-antimicrobial and cytotoxic-in host defense. In this study, we evaluated the antimicrobial and cytotoxic activities of histone H3 and identified the responsible molecular regions for these properties. Broth microdilution assays indicated that histone H3 exhibi...