Bone Marrow-Derived Mesenchymal Stem Cells and γ-Secretase Inhibitor Treatments Suppress Amyloid-β25-35-Induced Cognitive Impairment in Rat Dams and Cortical Degeneration in Offspring

• Main Authors: Asmaa Gaber (Author), Ahlam M. Elbakry (Author), Rabab M. Aljarari (Author), Fatima A. Jaber (Author), Yasser A. Khadrawy (Author), Dina Sabry (Author), Rasha E. Abo-ELeneen (Author), Osama M. Ahmed (Author)
• Format: Book
• Published: Hindawi Limited, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) is the most frequent cause of age-related neurodegeneration and ensuing cognitive impairment. Progressive deposition of extracellular amyloid beta (Aβ) aggregates (plaques) and intracellular hyperphosphorylated Tau protein (p-Tau) are the core pathological markers of AD...