Alternative splicing for tuneable expression of protein subunits at desired ratios

• Autori principali: Christel Aebischer-Gumy (Autore), Pierre Moretti (Autore), Timothee Brunstein Laplace (Autore), Jana Frank (Autore), Ysaline Grand (Autore), Farid Mosbaoui (Autore), Emilie Hily (Autore), Anna Galea (Autore), Megane Peltret (Autore), Carole Estoppey (Autore), Daniel Ayoub (Autore), Roberto Giovannini (Autore), Martin Bertschinger (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

ABSTRACTThe controlled expression of two or more proteins at a defined and stable ratio remains a substantial challenge, particularly in the bi- and multispecific antibody field. Achieving an optimal ratio of protein subunits can facilitate the assembly of multimeric proteins with high efficiency an...