Technical approaches for mouse models of human disease

• Autori principali: Monica J. Justice (Autore), Linda D. Siracusa (Autore), A. Francis Stewart (Autore)
• Natura: Libro
• Pubblicazione: The Company of Biologists, 2011-05-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The mouse is the leading organism for disease research. A rich resource of genetic variation occurs naturally in inbred and special strains owing to spontaneous mutations. However, one can also obtain desired gene mutations by using the following processes: targeted mutations that eliminate function...