Metabolism-Guided Optimization of Tryptophanol-Derived Isoindolinone p53 Activators

Metabolism-Guided Optimization of Tryptophanol-Derived Isoindolinone p53 Activators

For the first time, the pharmacokinetic (PK) profile of tryptophanol-derived isoindolinones, previously reported as p53 activators, was investigated. From the metabolites' identification, performed by liquid chromatography coupled to high resolution tandem mass spectrometry (LC-HRMS/MS), follow...

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Main Authors: Valentina Barcherini (Author), Joana B. Loureiro (Author), Ana Sena (Author), Catarina Madeira (Author), Paula Leandro (Author), Lucília Saraiva (Author), Alexandra M. M. Antunes (Author), Maria M. M. Santos (Author)
Format: Book
Published: MDPI AG, 2023-01-01T00:00:00Z.
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3rd Floor Main Library

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