Metabolism-Guided Optimization of Tryptophanol-Derived Isoindolinone p53 Activators

• मुख्य लेखकों: Valentina Barcherini (लेखक), Joana B. Loureiro (लेखक), Ana Sena (लेखक), Catarina Madeira (लेखक), Paula Leandro (लेखक), Lucília Saraiva (लेखक), Alexandra M. M. Antunes (लेखक), Maria M. M. Santos (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

For the first time, the pharmacokinetic (PK) profile of tryptophanol-derived isoindolinones, previously reported as p53 activators, was investigated. From the metabolites' identification, performed by liquid chromatography coupled to high resolution tandem mass spectrometry (LC-HRMS/MS), follow...