Umuhengerin Neuroprotective Effects in Streptozotocin-Induced Alzheimer's Disease Mouse Model via Targeting Nrf2 and NF-Kβ Signaling Cascades

• Main Authors: Alaa Sirwi (Author), Nesrine S. El Sayed (Author), Hossam M. Abdallah (Author), Sabrin R. M. Ibrahim (Author), Gamal A. Mohamed (Author), Ali M. El-Halawany (Author), Martin K. Safo (Author), Nora O. Abdel Rasheed (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) is the most common type of dementia and is characterized by advanced cognitive deterioration, deposition of Aβ (amyloid-beta), and the formation of neurofibrillary tangles. Administration of streptozotocin (STZ) via the intracerebroventricular (ICV) route is a reliable...