Effects of a spleen tyrosine kinase inhibitor on progression of the lupus nephritis in mice

• Main Authors: Maki Kitai (Author), Noboru Fukuda (Author), Takahiro Ueno (Author), Morito Endo (Author), Takashi Maruyama (Author), Masanori Abe (Author), Kazuyoshi Okada (Author), Masayoshi Soma (Author), Koichi Matsumoto (Author)
• Format: Book
• Published: Elsevier, 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Fc receptors (FcR) have pivotal roles in the pathogenesis of the autoimmune glomerulonephritis. We therefore investigated the effects of a Syk inhibitor on the progression of lupus nephritis and SH3 domain binding protein 2 and p38MAP kinase signalings in mice. NZB/W F1 mice, a model of lupus ne...