Selective histamine H2 receptor agonists alleviate blood-brain barrier disruption by promoting the expression of vascular protective factors following traumatic brain injury in mice

• Main Authors: Shotaro Michinaga (Author), Kiyomi Sonoda (Author), Naoki Inazuki (Author), Manae Ezaki (Author), Hiroki Awane (Author), Kahori Shimizu (Author), Shigeru Hishinuma (Author), Hiroyuki Mizuguchi (Author)
• Format: Book
• Published: Elsevier, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Histamine is a major neurotransmitter and alleviates neuronal damage after ischemic injury via H2 receptors. Herein, we investigated the effects of H2 receptor agonists on the blood-brain barrier (BBB) disruption after traumatic brain injury (TBI). Male ddY mice were used to generate the TBI model,...