Selective histamine H2 receptor agonists alleviate blood-brain barrier disruption by promoting the expression of vascular protective factors following traumatic brain injury in mice

• Principais autores: Shotaro Michinaga (Autor), Kiyomi Sonoda (Autor), Naoki Inazuki (Autor), Manae Ezaki (Autor), Hiroki Awane (Autor), Kahori Shimizu (Autor), Shigeru Hishinuma (Autor), Hiroyuki Mizuguchi (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2022-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Histamine is a major neurotransmitter and alleviates neuronal damage after ischemic injury via H2 receptors. Herein, we investigated the effects of H2 receptor agonists on the blood-brain barrier (BBB) disruption after traumatic brain injury (TBI). Male ddY mice were used to generate the TBI model,...