PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo

• Autori principali: Alexia Chauzy (Autore), Grace Akrong (Autore), Vincent Aranzana-Climent (Autore), Jérémy Moreau (Autore), Laure Prouvensier (Autore), Hélène Mirfendereski (Autore), Julien M Buyck (Autore), William Couet (Autore), Sandrine Marchand (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The reduction in antimicrobial activity at high bacterial counts is a microbiological phenomenon known as the inoculum effect (IE). In a previous in vitro study, a significant IE was observed for polymyxin B (PMB) against a clinical isolate of Acinetobacter baumannii, and well described by a new pha...