PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo

• Autores principales: Alexia Chauzy (Autor), Grace Akrong (Autor), Vincent Aranzana-Climent (Autor), Jérémy Moreau (Autor), Laure Prouvensier (Autor), Hélène Mirfendereski (Autor), Julien M Buyck (Autor), William Couet (Autor), Sandrine Marchand (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

The reduction in antimicrobial activity at high bacterial counts is a microbiological phenomenon known as the inoculum effect (IE). In a previous in vitro study, a significant IE was observed for polymyxin B (PMB) against a clinical isolate of Acinetobacter baumannii, and well described by a new pha...