PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo

• Main Authors: Alexia Chauzy (Author), Grace Akrong (Author), Vincent Aranzana-Climent (Author), Jérémy Moreau (Author), Laure Prouvensier (Author), Hélène Mirfendereski (Author), Julien M Buyck (Author), William Couet (Author), Sandrine Marchand (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The reduction in antimicrobial activity at high bacterial counts is a microbiological phenomenon known as the inoculum effect (IE). In a previous in vitro study, a significant IE was observed for polymyxin B (PMB) against a clinical isolate of Acinetobacter baumannii, and well described by a new pha...