Association between high-dose methotrexate-induced toxicity and polymorphisms within methotrexate pathway genes in acute lymphoblastic leukemia

• Main Authors: Meng Xu (Author), Shuangshuang Wu (Author), Yue Wang (Author), Yundong Zhao (Author), Ximin Wang (Author), Changhong Wei (Author), Xueying Liu (Author), Feng Hao (Author), Cheng Hu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Methotrexate (MTX) is a folic acid antagonist, the mechanism of action is to inhibit DNA synthesis, repair and cell proliferation by decreasing the activities of several folate-dependent enzymes. It is widely used as a chemotherapy drug for children and adults with malignant tumors. High-dose methot...