Association between high-dose methotrexate-induced toxicity and polymorphisms within methotrexate pathway genes in acute lymphoblastic leukemia

• প্রধান লেখক: Meng Xu (লেখক), Shuangshuang Wu (লেখক), Yue Wang (লেখক), Yundong Zhao (লেখক), Ximin Wang (লেখক), Changhong Wei (লেখক), Xueying Liu (লেখক), Feng Hao (লেখক), Cheng Hu (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Methotrexate (MTX) is a folic acid antagonist, the mechanism of action is to inhibit DNA synthesis, repair and cell proliferation by decreasing the activities of several folate-dependent enzymes. It is widely used as a chemotherapy drug for children and adults with malignant tumors. High-dose methot...