Association between high-dose methotrexate-induced toxicity and polymorphisms within methotrexate pathway genes in acute lymphoblastic leukemia

• Hoofdauteurs: Meng Xu (Auteur), Shuangshuang Wu (Auteur), Yue Wang (Auteur), Yundong Zhao (Auteur), Ximin Wang (Auteur), Changhong Wei (Auteur), Xueying Liu (Auteur), Feng Hao (Auteur), Cheng Hu (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Methotrexate (MTX) is a folic acid antagonist, the mechanism of action is to inhibit DNA synthesis, repair and cell proliferation by decreasing the activities of several folate-dependent enzymes. It is widely used as a chemotherapy drug for children and adults with malignant tumors. High-dose methot...