Aryl Hydrocarbon Receptor-Dependent and -Independent Pathways Mediate Curcumin Anti-Aging Effects

• Main Authors: Vanessa Brinkmann (Author), Margherita Romeo (Author), Lucie Larigot (Author), Anne Hemmers (Author), Lisa Tschage (Author), Jennifer Kleinjohann (Author), Alfonso Schiavi (Author), Swantje Steinwachs (Author), Charlotte Esser (Author), Ralph Menzel (Author), Sara Giani Tagliabue (Author), Laura Bonati (Author), Fiona Cox (Author), Niloofar Ale-Agha (Author), Philipp Jakobs (Author), Joachim Altschmied (Author), Judith Haendeler (Author), Xavier Coumoul (Author), Natascia Ventura (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose activity can be modulated by polyphenols, such as curcumin. AhR and curcumin have evolutionarily conserved effects on aging. Here, we investigated whether and how the AhR mediates the anti-aging effects of curcumin...