Synthesis and antiviral activity of a series of novel N-phenylbenzamide and N-phenylacetophenone compounds as anti-HCV and anti-EV71 agents
A series of novel N-phenylbenzamide and N-phenylacetophenone compounds were synthesized and evaluated for their antiviral activity against HCV and EV71 (strain SZ-98). The biological results showed that three compounds (23, 25 and 41) exhibited considerable anti-HCV activity (IC50=0.57-7.12 μmol/L)...
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| Main Authors: | , , , , , |
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| Format: | Book |
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Elsevier,
2015-05-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_fb01be7dbaed414cb38f6f5bea6c99d1 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Zhi Jiang |e author |
| 700 | 1 | 0 | |a Huiqiang Wang |e author |
| 700 | 1 | 0 | |a Yanping Li |e author |
| 700 | 1 | 0 | |a Zonggen Peng |e author |
| 700 | 1 | 0 | |a Yuhuan Li |e author |
| 700 | 1 | 0 | |a Zhuorong Li |e author |
| 245 | 0 | 0 | |a Synthesis and antiviral activity of a series of novel N-phenylbenzamide and N-phenylacetophenone compounds as anti-HCV and anti-EV71 agents |
| 260 | |b Elsevier, |c 2015-05-01T00:00:00Z. | ||
| 500 | |a 2211-3835 | ||
| 500 | |a 2211-3843 | ||
| 500 | |a 10.1016/j.apsb.2015.03.013 | ||
| 520 | |a A series of novel N-phenylbenzamide and N-phenylacetophenone compounds were synthesized and evaluated for their antiviral activity against HCV and EV71 (strain SZ-98). The biological results showed that three compounds (23, 25 and 41) exhibited considerable anti-HCV activity (IC50=0.57-7.12 μmol/L) and several compounds (23, 28, 29, 30, 31 and 42) displayed potent activity against EV71 with the IC50 values lower than 5.00 μmol/L. The potency of compound 23 (IC50=0.57 μmol/L) was superior to that of reported compounds IMB-1f (IC50=1.90 μmol/L) and IMB-1g (IC50=1.00 μmol/L) as anti-HCV agents, and compound 29 possessed the highest anti-EV71 activity, comparable to the comparator drug pirodavir. The efficacy in vivo and antiviral mechanism of these compounds warrant further investigations. | ||
| 546 | |a EN | ||
| 690 | |a Synthesis | ||
| 690 | |a N-phenylbenzamide | ||
| 690 | |a N-phenylacetophenone | ||
| 690 | |a Anti-HCV | ||
| 690 | |a Anti-EV71 | ||
| 690 | |a Agents | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Acta Pharmaceutica Sinica B, Vol 5, Iss 3, Pp 201-209 (2015) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S221138351500057X | |
| 787 | 0 | |n https://doaj.org/toc/2211-3835 | |
| 787 | 0 | |n https://doaj.org/toc/2211-3843 | |
| 856 | 4 | 1 | |u https://doaj.org/article/fb01be7dbaed414cb38f6f5bea6c99d1 |z Connect to this object online. |