In Vitro Evaluation of Aerosol Therapy with Pentamidine-Loaded Liposomes Coated with Chondroitin Sulfate or Heparin for the Treatment of Leishmaniasis

• Main Authors: Lucía Román-Álamo (Author), Mohamad Allaw (Author), Yunuen Avalos-Padilla (Author), Maria Letizia Manca (Author), Maria Manconi (Author), Federica Fulgheri (Author), Jorge Fernández-Lajo (Author), Luis Rivas (Author), José Antonio Vázquez (Author), José Esteban Peris (Author), Xavier Roca-Geronès (Author), Srisupaph Poonlaphdecha (Author), Maria Magdalena Alcover (Author), Roser Fisa (Author), Cristina Riera (Author), Xavier Fernàndez-Busquets (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The second-line antileishmanial compound pentamidine is administered intramuscularly or, preferably, by intravenous infusion, with its use limited by severe adverse effects, including diabetes, severe hypoglycemia, myocarditis and renal toxicity. We sought to test the potential of phospholipid vesic...