Potentiation of PIEZO2 mechanically-activated currents in sensory neurons mediates vincristine-induced mechanical hypersensitivity

• Glavni autori: Mingli Duan (Autor), Yurui Jia (Autor), Lifang Huo (Autor), Yiting Gao (Autor), Jia Wang (Autor), Wei Zhang (Autor), Zhanfeng Jia (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2023-08-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Vincristine, a widely used chemotherapeutic agent for treating different cancer, often induces severe peripheral neuropathic pain. A common symptom of vincristine-induced peripheral neuropathic pain is mechanical allodynia and hyperalgesia. However, mechanisms underlying vincristine-induced mechanic...