Potentiation of PIEZO2 mechanically-activated currents in sensory neurons mediates vincristine-induced mechanical hypersensitivity

• Egile Nagusiak: Mingli Duan (Egilea), Yurui Jia (Egilea), Lifang Huo (Egilea), Yiting Gao (Egilea), Jia Wang (Egilea), Wei Zhang (Egilea), Zhanfeng Jia (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2023-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Vincristine, a widely used chemotherapeutic agent for treating different cancer, often induces severe peripheral neuropathic pain. A common symptom of vincristine-induced peripheral neuropathic pain is mechanical allodynia and hyperalgesia. However, mechanisms underlying vincristine-induced mechanic...