Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology

• প্রধান লেখক: Ying Wang (লেখক), Masahiro Kanai (লেখক), Taotao Tan (লেখক), Mireille Kamariza (লেখক), Kristin Tsuo (লেখক), Kai Yuan (লেখক), Wei Zhou (লেখক), Yukinori Okada (লেখক), Hailiang Huang (লেখক), Patrick Turley (লেখক), Elizabeth G. Atkinson (লেখক), Alicia R. Martin (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2023-10-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Summary: Polygenic risk scores (PRSs) developed from multi-ancestry genome-wide association studies (GWASs), PRSmulti, hold promise for improving PRS accuracy and generalizability across populations. To establish best practices for leveraging the increasing diversity of genomic studies, we investiga...