Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology

• Main Authors: Ying Wang (Author), Masahiro Kanai (Author), Taotao Tan (Author), Mireille Kamariza (Author), Kristin Tsuo (Author), Kai Yuan (Author), Wei Zhou (Author), Yukinori Okada (Author), Hailiang Huang (Author), Patrick Turley (Author), Elizabeth G. Atkinson (Author), Alicia R. Martin (Author)
• Format: Book
• Published: Elsevier, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Polygenic risk scores (PRSs) developed from multi-ancestry genome-wide association studies (GWASs), PRSmulti, hold promise for improving PRS accuracy and generalizability across populations. To establish best practices for leveraging the increasing diversity of genomic studies, we investiga...