Orthotopic and heterotopic murine models of pancreatic cancer and their different responses to FOLFIRINOX chemotherapy

• Autori principali: Derek J. Erstad (Autore), Mozhdeh Sojoodi (Autore), Martin S. Taylor (Autore), Sarani Ghoshal (Autore), Allen A. Razavi (Autore), Katherine A. Graham-O'Regan (Autore), Nabeel Bardeesy (Autore), Cristina R. Ferrone (Autore), Michael Lanuti (Autore), Peter Caravan (Autore), Kenneth K. Tanabe (Autore), Bryan C. Fuchs (Autore)
• Natura: Libro
• Pubblicazione: The Company of Biologists, 2018-07-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Syngeneic, immunocompetent allograft tumor models recapitulate important aspects of the tumor microenvironment and have short tumor latency with predictable growth kinetics, making them useful for trialing novel therapeutics. Here, we describe surgical techniques for orthotopic and heterotopic pancr...