Orthotopic and heterotopic murine models of pancreatic cancer and their different responses to FOLFIRINOX chemotherapy

• Main Authors: Derek J. Erstad (Author), Mozhdeh Sojoodi (Author), Martin S. Taylor (Author), Sarani Ghoshal (Author), Allen A. Razavi (Author), Katherine A. Graham-O'Regan (Author), Nabeel Bardeesy (Author), Cristina R. Ferrone (Author), Michael Lanuti (Author), Peter Caravan (Author), Kenneth K. Tanabe (Author), Bryan C. Fuchs (Author)
• Format: Book
• Published: The Company of Biologists, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Syngeneic, immunocompetent allograft tumor models recapitulate important aspects of the tumor microenvironment and have short tumor latency with predictable growth kinetics, making them useful for trialing novel therapeutics. Here, we describe surgical techniques for orthotopic and heterotopic pancr...