Investigation of factors that cause insulin precipitation and/or amyloid formation in insulin formulations

• Principais autores: Yui Ohno (Autor), Tomohiro Seki (Autor), Yu Kojima (Autor), Ryotaro Miki (Autor), Yuya Egawa (Autor), Osamu Hosoya (Autor), Keizo Kasono (Autor), Toshinobu Seki (Autor)
• Formato: Livro
• Publicado em: BMC, 2019-10-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background Multiple daily subcutaneous injections (MDSIs) are mainly used for formulating an insulin therapy for diabetic patients; however, they also cause insulin-derived amyloidosis (IDA) and lead to poor glycemic control. In addition, for the continuous subcutaneous insulin infusion sys...