Karanjin interferes with ABCB1, ABCC1, and ABCG2

• Main Authors: Martin Michaelis (Author), Florian Rothweiler (Author), Thomas Nerreter (Author), Mohsen Sharifi (Author), Taravat Ghafourian (Author), Jindrich Cinatl (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PURPOSE: The prominent ATP-binding cassette (ABC) transporters ABCB1, ABCC1, and ABCG2 are involved in substance transport across physiological barriers and therefore in drug absorption, distribution, and elimination. They also mediate multi-drug resistance in cancer cells. Different flavonoids are...