Streamlined DNA-encoded small molecule library screening and validation for the discovery of novel chemotypes targeting BET proteins

• 主要な著者: Seoyeon Jeong (著者), Hwa-Ryeon Kim (著者), June-Ha Shin (著者), Min-Hee Son (著者), In-Hyun Lee (著者), Jae-Seok Roe (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2023-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Targeting aberrant epigenetic programs that drive tumorigenesis is a promising approach to cancer therapy. DNA-encoded library (DEL) screening is a core platform technology increasingly used to identify drugs that bind to protein targets. Here, we use DEL screening against bromodomain and extra-term...