Streamlined DNA-encoded small molecule library screening and validation for the discovery of novel chemotypes targeting BET proteins

• Główni autorzy: Seoyeon Jeong (Autor), Hwa-Ryeon Kim (Autor), June-Ha Shin (Autor), Min-Hee Son (Autor), In-Hyun Lee (Autor), Jae-Seok Roe (Autor)
• Format: Książka
• Wydane: Elsevier, 2023-06-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Targeting aberrant epigenetic programs that drive tumorigenesis is a promising approach to cancer therapy. DNA-encoded library (DEL) screening is a core platform technology increasingly used to identify drugs that bind to protein targets. Here, we use DEL screening against bromodomain and extra-term...