Streamlined DNA-encoded small molecule library screening and validation for the discovery of novel chemotypes targeting BET proteins

• Main Authors: Seoyeon Jeong (Author), Hwa-Ryeon Kim (Author), June-Ha Shin (Author), Min-Hee Son (Author), In-Hyun Lee (Author), Jae-Seok Roe (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeting aberrant epigenetic programs that drive tumorigenesis is a promising approach to cancer therapy. DNA-encoded library (DEL) screening is a core platform technology increasingly used to identify drugs that bind to protein targets. Here, we use DEL screening against bromodomain and extra-term...