Design, synthesis, anti-inflammatory evaluation, and molecular modelling of new coumarin-based analogs combined curcumin and other heterocycles as potential TNF-α production inhibitors via upregulating Nrf2/HO-1, downregulating AKT/mTOR signalling pathways and downregulating NF-κB in LPS induced macrophages

• Main Authors: Lina M. A. Abdel Ghany (Author), Botros Y. Beshay (Author), Amal M. Youssef Moustafa (Author), Ali Hassan Ahmed Maghrabi (Author), Eman Hussain Khalifa Ali (Author), Rasha Mohammed Saleem (Author), Islam Zaki (Author), Noha Ryad (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Persistent inflammation contributes to various inflammatory conditions. Inflammation-related diseases may be treated by inhibiting pro-inflammatory mediators and cytokines. Curcumin and coumarin derivatives can target signalling pathways and cellular factors to address immune-related and inflammator...