Design, synthesis, anti-inflammatory evaluation, and molecular modelling of new coumarin-based analogs combined curcumin and other heterocycles as potential TNF-α production inhibitors via upregulating Nrf2/HO-1, downregulating AKT/mTOR signalling pathways and downregulating NF-κB in LPS induced macrophages

• Үндсэн зохиолчид: Lina M. A. Abdel Ghany (Зохиогч), Botros Y. Beshay (Зохиогч), Amal M. Youssef Moustafa (Зохиогч), Ali Hassan Ahmed Maghrabi (Зохиогч), Eman Hussain Khalifa Ali (Зохиогч), Rasha Mohammed Saleem (Зохиогч), Islam Zaki (Зохиогч), Noha Ryad (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Persistent inflammation contributes to various inflammatory conditions. Inflammation-related diseases may be treated by inhibiting pro-inflammatory mediators and cytokines. Curcumin and coumarin derivatives can target signalling pathways and cellular factors to address immune-related and inflammator...