The TLR4-active morphine metabolite morphine-3-glucuronide does not elicit macrophage classical activation in vitro

• Główni autorzy: Samira Khabbazi (Autor), Nan Xie (Autor), Wenjun Pu (Autor), Yannick Goumon (Autor), Marie-Odile Parat (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2016-11-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Macrophages are abundant in the tumor microenvironment where they adopt a pro-tumor phenotype following alternative polarization induced by paracrine factors from cancer and stromal cells. In contrast, classically activated macrophages have tumoricidal activities, such that the polarization of tumor...