An ACE2-IgG4 Fc Fusion Protein Demonstrates Strong Binding to All Tested SARS-CoV-2 Variants and Reduced Lung Inflammation in Animal Models of SARS-CoV-2 and Influenza

• Asıl Yazarlar: Emmanuel Merigeon (Yazar), Dong Yang (Yazar), Elizabeth Ihms (Yazar), Leda Bassit (Yazar), Elizabeth Fitzpatrick (Yazar), Colleen Jonsson (Yazar), Raymond Schinazi (Yazar), David Block (Yazar), Henrik Olsen (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Case Western Reserve University, 2022-08-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Background: The continued emergence of SARS-CoV-2 variants has caused concern that a constantly evolving virus will escape vaccines and antibody therapies. New approaches are needed. Methods: We created and manufactured an ACE2 extracellular domain (ECD) fragment Fc fusion drug candidate, G921, and...