An ACE2-IgG4 Fc Fusion Protein Demonstrates Strong Binding to All Tested SARS-CoV-2 Variants and Reduced Lung Inflammation in Animal Models of SARS-CoV-2 and Influenza

• Príomhchruthaitheoirí: Emmanuel Merigeon (Údar), Dong Yang (Údar), Elizabeth Ihms (Údar), Leda Bassit (Údar), Elizabeth Fitzpatrick (Údar), Colleen Jonsson (Údar), Raymond Schinazi (Údar), David Block (Údar), Henrik Olsen (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Case Western Reserve University, 2022-08-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Background: The continued emergence of SARS-CoV-2 variants has caused concern that a constantly evolving virus will escape vaccines and antibody therapies. New approaches are needed. Methods: We created and manufactured an ACE2 extracellular domain (ECD) fragment Fc fusion drug candidate, G921, and...