An ACE2-IgG4 Fc Fusion Protein Demonstrates Strong Binding to All Tested SARS-CoV-2 Variants and Reduced Lung Inflammation in Animal Models of SARS-CoV-2 and Influenza

• Main Authors: Emmanuel Merigeon (Author), Dong Yang (Author), Elizabeth Ihms (Author), Leda Bassit (Author), Elizabeth Fitzpatrick (Author), Colleen Jonsson (Author), Raymond Schinazi (Author), David Block (Author), Henrik Olsen (Author)
• Format: Book
• Published: Case Western Reserve University, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The continued emergence of SARS-CoV-2 variants has caused concern that a constantly evolving virus will escape vaccines and antibody therapies. New approaches are needed. Methods: We created and manufactured an ACE2 extracellular domain (ECD) fragment Fc fusion drug candidate, G921, and...