An ACE2-IgG4 Fc Fusion Protein Demonstrates Strong Binding to All Tested SARS-CoV-2 Variants and Reduced Lung Inflammation in Animal Models of SARS-CoV-2 and Influenza

• मुख्य लेखकों: Emmanuel Merigeon (लेखक), Dong Yang (लेखक), Elizabeth Ihms (लेखक), Leda Bassit (लेखक), Elizabeth Fitzpatrick (लेखक), Colleen Jonsson (लेखक), Raymond Schinazi (लेखक), David Block (लेखक), Henrik Olsen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Case Western Reserve University, 2022-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Background: The continued emergence of SARS-CoV-2 variants has caused concern that a constantly evolving virus will escape vaccines and antibody therapies. New approaches are needed. Methods: We created and manufactured an ACE2 extracellular domain (ECD) fragment Fc fusion drug candidate, G921, and...