Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII

• Päätekijät: João A. Abrantes (Tekijä), Alexander Solms (Tekijä), Dirk Garmann (Tekijä), Elisabet I. Nielsen (Tekijä), Siv Jönsson (Tekijä), Mats O. Karlsson (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Wiley, 2019-12-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Bayesian forecasting for dose individualization of prophylactic factor VIII replacement therapy using pharmacokinetic samples is challenged by large interindividual variability in the bleeding risk. A pharmacokinetic‐repeated time‐to‐event model‐based forecasting approach was developed to contrast t...