Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII

• Váldodahkkit: João A. Abrantes (Dahkki), Alexander Solms (Dahkki), Dirk Garmann (Dahkki), Elisabet I. Nielsen (Dahkki), Siv Jönsson (Dahkki), Mats O. Karlsson (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Wiley, 2019-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Bayesian forecasting for dose individualization of prophylactic factor VIII replacement therapy using pharmacokinetic samples is challenged by large interindividual variability in the bleeding risk. A pharmacokinetic‐repeated time‐to‐event model‐based forecasting approach was developed to contrast t...