Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates

ABSTRACTSoluble aggregates are reported to be the most neurotoxic species of α-Synuclein (αSyn) in Parkinson's disease (PD) and hence are a promising target for diagnosis and treatment of PD. However, the predominantly intracellular location of αSyn limits its accessibility, especially for anti...

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Main Authors: Inga Petersen (Author), Muhammad Ilyas Ali (Author), Alex Petrovic (Author), Anders Jimmy Ytterberg (Author), Karin Staxäng (Author), Monika Hodik (Author), Fadi Rofo (Author), Sina Bondza (Author), Greta Hultqvist (Author)
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Publicado: Taylor & Francis Group, 2023-12-01T00:00:00Z.
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Número de Clasificación: A1234.567
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