Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates

• Auteurs principaux: Inga Petersen (Auteur), Muhammad Ilyas Ali (Auteur), Alex Petrovic (Auteur), Anders Jimmy Ytterberg (Auteur), Karin Staxäng (Auteur), Monika Hodik (Auteur), Fadi Rofo (Auteur), Sina Bondza (Auteur), Greta Hultqvist (Auteur)
• Format: Livre
• Publié: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

ABSTRACTSoluble aggregates are reported to be the most neurotoxic species of α-Synuclein (αSyn) in Parkinson's disease (PD) and hence are a promising target for diagnosis and treatment of PD. However, the predominantly intracellular location of αSyn limits its accessibility, especially for anti...