Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates

• Main Authors: Inga Petersen (Author), Muhammad Ilyas Ali (Author), Alex Petrovic (Author), Anders Jimmy Ytterberg (Author), Karin Staxäng (Author), Monika Hodik (Author), Fadi Rofo (Author), Sina Bondza (Author), Greta Hultqvist (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTSoluble aggregates are reported to be the most neurotoxic species of α-Synuclein (αSyn) in Parkinson's disease (PD) and hence are a promising target for diagnosis and treatment of PD. However, the predominantly intracellular location of αSyn limits its accessibility, especially for anti...