Inhibitory Effect of Luteolin on Spike S1 Glycoprotein-Induced Inflammation in THP-1 Cells via the ER Stress-Inducing Calcium/CHOP/MAPK Pathway

• Main Authors: Sonthaya Umsumarng (Author), Sivamoke Dissook (Author), Punnida Arjsri (Author), Kamonwan Srisawad (Author), Pilaiporn Thippraphan (Author), Apiwat Sangphukieo (Author), Patcharawadee Thongkumkoon (Author), Pornngarm Dejkriengkraikul (Author)
• Format: Book
• Published: MDPI AG, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Objectives: The global SARS-CoV-2 outbreak has escalated into a critical public health emergency, with the spike glycoprotein S1 subunit of SARS-CoV-2 (spike-S1) linked to inflammation in lung tissue and immune cells. Luteolin, a flavone with anti-inflammatory properties, shows promise, b...