Morphing Natural Product Platensimycin via Heck, Sonogashira, and One-Pot Sonogashira/Cycloaddition Reactions to Produce Antibiotics with In Vivo Activity
Type II fatty acid synthases are promising drug targets against major bacterial pathogens. Platensimycin (PTM) is a potent inhibitor against <i>β</i>-ketoacyl-[acyl carrier protein] synthase II (FabF) and <i>β</i>-ketoacyl-[acyl carrier protein] synthase I (FabB), while the p...
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Format: | Book |
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MDPI AG,
2022-03-01T00:00:00Z.
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A1234.567 |
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Copy 1 | Available |