Upregulation of expression of the chemokine receptor CCR5 by hydrogen peroxide in human monocytes

• Үндсэн зохиолчид: Geneviève Lehoux (Зохиогч), Christian Le Gouill (Зохиогч), Jana Stankova (Зохиогч), Marek Rola-pleszczynski (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Hindawi Limited, 2003-01-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

The objective of this study was to test the hypothesis that an oxidative stress can serve as a signal to regulate the expression of CCR5. When human monocytes were exposed to graded concentration of hydrogen peroxide (H2O2), CCR5 mRNA levels increased maximally at 4 h of exposure to 200 μM of H2O2 a...