Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models.

• Main Authors: Hanna T Sjoberg (Author), Nicolas Pionnier (Author), Ghaith Aljayyoussi (Author), Haelly M Metuge (Author), Abdel J Njouendou (Author), Valerine C Chunda (Author), Fanny F Fombad (Author), Dizzle B Tayong (Author), Narcisse V T Gandjui (Author), Desmond N Akumtoh (Author), Patrick W N Chounna (Author), Bertrand L Ndzeshang (Author), Sophie Lachaud (Author), Fetene Tekle (Author), Ludo Quirynen (Author), Marc Engelen (Author), Benny Baeten (Author), Andrew Steven (Author), Stephen A Ward (Author), Mark J Taylor (Author), Samuel Wanji (Author), Joseph D Turner (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Onchocerca ochengi adult implant and Brugia malayi microfilariemic Severe-Combined Immunodeficient (SCID) mouse models are validated screens to measure macrofilaricidal and microfilaricidal activities of candidate onchocerciasis drugs. The purpose of this study was to assess whether 5 daily sub-...