Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models.

• Автори: Hanna T Sjoberg (Автор), Nicolas Pionnier (Автор), Ghaith Aljayyoussi (Автор), Haelly M Metuge (Автор), Abdel J Njouendou (Автор), Valerine C Chunda (Автор), Fanny F Fombad (Автор), Dizzle B Tayong (Автор), Narcisse V T Gandjui (Автор), Desmond N Akumtoh (Автор), Patrick W N Chounna (Автор), Bertrand L Ndzeshang (Автор), Sophie Lachaud (Автор), Fetene Tekle (Автор), Ludo Quirynen (Автор), Marc Engelen (Автор), Benny Baeten (Автор), Andrew Steven (Автор), Stephen A Ward (Автор), Mark J Taylor (Автор), Samuel Wanji (Автор), Joseph D Turner (Автор)
• Формат: Книга
• Опубліковано: Public Library of Science (PLoS), 2019-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The Onchocerca ochengi adult implant and Brugia malayi microfilariemic Severe-Combined Immunodeficient (SCID) mouse models are validated screens to measure macrofilaricidal and microfilaricidal activities of candidate onchocerciasis drugs. The purpose of this study was to assess whether 5 daily sub-...